NIH strongly recommends that you include a cover letter with your application indicating the specific NIH Institute or Center (IC) that you believe should have primary assignment of your application, and which review committee would be most appropriate to review the application. The Center for Scientific Review (CSR) retains the responsibility for making the final determinations concerning assignment of applications to an IC and a particular review committee (study section) at CSR . However, it is in your best interest to be familiar with the available choices and to express your opinion in the cover letter.